Description
Resistance and Compliance (RC) is a technique that measures respiratory flow and transpulmonary pressure to compute airway resistance and compliance. The animal is anaesthetised, and tracheotomised or intubated, and placed in the plethysmograph. Depending on the species and application, the animal can be either spontaneously breathing or connected to a ventilator.
Advantages
Can be combined with in-line aerosol delivery for dose response studies.
Provides continuous measurement of RC.
Multiple animals can be measured simultaneously.
Possible to use tracheotomised or intubated animals.
Option for tail-out access for IV administration.
Applications
Resistance and Compliance is a widely accepted measurement method for research into conditions such as asthma and lung inflammation.
The following list shows some of the parameters available:
| Name | Units | Description |
|---|---|---|
| TV | ml | Tidal Volume, volume inspired during one breath |
| tI | s | Inspiration time |
| tE | s | Expiration time |
| PIf | ml/s | Peak inspiratory flow |
| PEf | ml/s | Peak expiratory flow |
| f | breaths/minute | Frequency of breathing |
| MV | ml | Minute Volume, volume inspired in one minute |
| tR | s | Relaxation time |
| AV | ml | Accumulated volume |
| EIP | s | End inspiratory pause |
| EEP | s | End expiratory pause |
| VolBal | % | Difference between inspiratory/expiratory volume |
| Rl | cmH2O/ml/s | Lung Resistance |
| Cdyn | ml/cmH2O | Lung Compliance |
| DPpl | cmH2O | Developed pressure |
| Cl | ml/s/cmH2O | Lung Conductance |
| RlOffset | cmH2O/ml/s | Resistance offset for cannula etc. |
| EF50 | ml/s | Expiratory flow at 50% of expired volume |
Specifications
The table below shows the standard chamber sizes for small animals. For larger animals, please see our Resistance and Compliance system for large animals.
| References | Species | Size Guidance |
|---|---|---|
| PLY 110 | Mouse | 15 to 30 g |
| PLY 120 | Rat | Up to 600 g |
| PLY 130 | Guinea Pig | Up to 1000 g |
| PLY 140 | Rabbit | Up to 2000 g |
Images
Selected References
IL-17A Modulates Oxidant Stress-Induced Airway Hyperresponsiveness but Not Emphysema
Mariona Pinart, Min Zhang, Feng Li, Farhana Hussain, Jie Zhu, Coen Wiegman, Bernard Ryffel, Kian Fan Chung
Intratracheal administration of adipose derived mesenchymal stem cells alleviates chronic asthma in a mouse model
Ranran Dai, Youchao Yu, Guofeng Yan, Xiaoxia Hou, Yingmeng Ni and Guochao Shi
Lung Macrophages Contribute to House Dust Mite Driven Airway Remodeling via HIF-1a
Adam J. Byrne , Carla P. Jones , Kate Gowers, Sara M. Rankin, Clare M. Lloyd
