Description
Head-Out Plethysmography (HOP) is a technique which measures the pressure changes caused by thoracic movements of an animal inside a sealed chamber. These pressure changes are directly proportional to respiratory flow. A latex seal is used to isolate the nose/mouth air flows.
Advantages
Ready to be used directly on inhalation towers for respiratory monitoring
Direct measurement of the thorax provides accurate data
Quick loading plunger to reduce animal stress
Option to have tail access from outside of the chamber
Option to add a nasal chamber for measurement of Specific Airway Resistance (SRaw)
Applications
Head-Out Plethysmography can be a very useful technique when accurate measurements are required on a conscious subject, or when access to the nose, mouth or tail are needed while monitoring respiratory parameters. It is commonly used in inhalation studies and Safety Pharmacology.
The following list shows some of the parameters available:
| Name | Units | Description |
|---|---|---|
| TV | ml | Tidal Volume, volume inspired during one breath |
| tI | s | Inspiration time |
| tE | s | Expiration time |
| PIf | mls/s | Peak inspiratory flow |
| PEf | mls/s | Peak expiratory flow |
| f | breaths/minute | Frequency of breathing |
| MV | ml | Minute Volume, volume inspired in one minute |
| tR | s | Relaxation time |
| AV | ml | Accumulated volume |
| EIP | s | End inspiratory pause |
| EEP | s | End expiratory pause |
| VolBal | % | Difference between inspiratory/expiratory volume |
| EF50 | ml/s | Expiratory flow @ 50% TV |
Specifications
The table below shows the standard chamber sizes. For any other species or sizes please contact us.
| References | Species | Size Guidance |
|---|---|---|
| PLY 212 | Mouse | 15 to 30 g |
| PLY 222 | Rat | Up to 250 g |
| PLY 222L | Rat, Ferret | More than 300 g |
| PLY 232S | Guinea Pig | Up to 500 g |
| PLY 232 | Guinea Pig | Up to 750 g |
Images
Selected References
Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague–Dawley rats
Joanna Seiffert, Alison Buckley, Bey Leo, Nicholas G. Martin, Jie Zhu, Ranran Dai, Farhana Hussain, Chang Guo, James Warren , Alan Hodgson, Jicheng Gong, Mary P. Ryan, Junfeng (Jim) Zhang, Alexandra Porter, Terry D. Tetley, Andrew Gow, Rachel Smith and Kian an Chung
Implications for Room Lighting and the Duration of Acclimation Protocols on the Dosimetry of Inhaled Drugs in Rats
Graham R. Paul, Graham I. Somers, and Glyn Taylor
描述
Description here
技术优势
Multiple sizes for different subject
Robust design
Large chambers include platform with wheels. One person can move the system to a different room
Low noise design
Camara to monitor the subjects. Signal and video recorded are recorded syncronized
CO2 monitoring
应用领域
Whole Body Plethysmography is a versatile system, and can be used for the following applications among others:
技术参数
The basic WBP analyzer allows to extract basic respiratory parameters:
| Name | Units | Description |
|---|---|---|
| TV | ml | Tidal Volume, volume inspired during one breath |
| tI | s | Inspiration time |
| tE | s | Expiration time |
| PIf | mls/s | Peak inspiratory flow |
| PEf | mls/s | Peak expiratory flow |
| f | breaths/minute | Frequency of breathing |
| MV | ml | Minute Volume, volume inspired in one minute |
| tR | s | Relaxation time |
| AV | ml | Accumulated volume |
| EIP | s | End inspiratory pause |
| EEP | s | End expiratory pause |
| Penh | (NONE) | Pause enhanced, index of constriction |
| VolBal | % | Difference between inspiratory/expiratory volume |
| Atm | mbar | Atmospheric pressure |
| Hum | % | Relative humidity in chamber |
| Temp | deg. C | Air temperature in chamber |
| BTemp | deg. C | Body temperature of animal |
| Corr | N/A | Drorbaugh & Fenn volume correction constant |
| NTemp | deg. C | Nasal temperature |
| AtoB | N/A | Epstein & Epstein A/B ratio |
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Specifications
图像
参考引用
Characterisation of Brachycephalic Obstructive Airway Syndrome in French Bulldogs Using Whole-Body Barometric Plethysmography
Nai-Chieh Liu, David R. Sargan, Vicki J. Adams, Jane F. Ladlow
Whole-Body Barometric Plethysmography Characterizes Upper Airway Obstruction in 3 Brachycephalic Breeds of Dogs
N-C. Liu, V.J. Adams, L. Kalmar, J.F. Ladlow, and D.R. Sargan
